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Effects, Doses, and Applicability of Gestrinone in Estrogen-Dependent Conditions and Post-Menopausal Women

Resource type
Authors/contributors
Title
Effects, Doses, and Applicability of Gestrinone in Estrogen-Dependent Conditions and Post-Menopausal Women
Abstract
Gestrinone (R-2323), or ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group more commonly used as an oral, intravaginal, or subcutaneous implant for the treatment of endometriosis, contraception, and estrogen-dependent conditions such as hypermenorrhea, premenstrual dysphoria, and intense menstrual cramps. This review aims to reevaluate the routes, doses, and applicability proposed for using gestrinone, including its use in new conditions such as menopause, lipedema, and sarcopenia. Here, we present the possible application of gestrinone as a long-acting therapeutic possibility through hormonal implants and the benefits and potential risks. Available evidence on the safety of doses and routes is limited. Gestrinone appears to be effective compared to other progestins and may have some advantages in the treatment of estrogen-dependent pathologies. Future research must evaluate gestrinone's long-term safety and potential therapeutic indications.
Publication
Pharmaceuticals (Basel, Switzerland)
Volume
17
Issue
9
Pages
1248
Date
2024-09-22
Journal Abbr
Pharmaceuticals (Basel)
Language
eng
ISSN
1424-8247
Library Catalog
PubMed
Citation
Renke, G., Antunes, M., Sakata, R., & Tostes, F. (2024). Effects, Doses, and Applicability of Gestrinone in Estrogen-Dependent Conditions and Post-Menopausal Women. Pharmaceuticals (Basel, Switzerland), 17(9), 1248. https://doi.org/10.3390/ph17091248
Publication